Long-Term Depression and Recognition of Parallel Fibre Patterns in a Multi-Compartmental Model of a Cerebellar Purkinje Cell

This week on Journal Club session Volker Steuber will talk about temporal coding and, in particular, rank order coding. Please see the papers below for more details.

It has been suggested that long-term depression (LTD) of parallel fibre (PF) synapses enables a cerebellar Purkinje cell (PC) to learn to recognise PF activity patterns. We investigate the recognition of PF patterns that have been stored by LTD of AMPA receptors in a multi- compartmental PC model with a passive soma. We find that a corresponding artificial neural network outperforms a PC model with active dendrites by an order of magnitude. Removal of the dendritic ion channels leads to a further decrease in performance. Another effect of the active dendrites is an afterhyperpolarization response to novel PF patterns. Thus, the LTD based storage of PF patterns can lead to a potentiated late PC response.


Date: 2022/07/01
Time: 14:00
Location: online

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