UH Biocomputation Group - geneticshttp://biocomputation.herts.ac.uk/2021-10-06T12:07:55+01:00Spinal Muscle Atrophy Disease Modelling as Bayesian Network2021-10-06T12:07:55+01:002021-10-06T12:07:55+01:00Manal Helaltag:biocomputation.herts.ac.uk,2021-10-06:/2021/10/06/spinal-muscle-atrophy-disease-modelling-as-bayesian-network.html<p class="first last">Manal Helal's Journal Club session where she will talk about her current work on "Spinal Muscle Atrophy Disease Modelling as Bayesian Network"</p>
<p>This week on Journal Club session Manal Helal will talk about her current work on "Spinal Muscle Atrophy Disease Modelling as Bayesian Network".</p>
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<p>We investigate the molecular gene expressions studies and public databases for
disease modelling using Probabilistic Graphical Models and Bayesian Inference.
A case study on Spinal Muscle Atrophy Genome-Wide Association Study results is
modelled and analyzed. The genes up and down-regulated in 2 stages of the
disease development are linked to prior knowledge published in the public
domain and co-expressions network is created and analyzed. The Molecular
Pathways triggered by these genes are identified. The Bayesian inference
posteriors distributions are estimated using a variational analytical algorithm
and a Markov chain Monte Carlo sampling algorithm. Assumptions, limitations and
possible future work are concluded.</p>
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<p><strong>Date:</strong> 2021/10/08 <br />
<strong>Time:</strong> 14:00 <br />
<strong>Location</strong>: online</p>
Interactions between Brassica Napus and Extracellular Fungal Pathogen Pyrenopeziza Brassicae2021-02-25T10:29:00+00:002021-02-25T10:29:00+00:00Chinthani Karandeni Dewagetag:biocomputation.herts.ac.uk,2021-02-25:/2021/02/25/interactions-between-brassica-napus-and-extracellular-fungal-pathogen-pyrenopeziza-brassicae.html<p class="first last">Chinthani Karandeni Dewage's Journal Club session where she will talk about a paper "Interactions between Brassica Napus and Extracellular Fungal Pathogen Pyrenopeziza Brassicae"</p>
<p>This week on Journal Club session Chinthani Karandeni Dewage will talk about a paper "Interactions between Brassica Napus and Extracellular Fungal Pathogen Pyrenopeziza Brassicae".</p>
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<p>Light leaf spot (Pyrenopeziza brassicae) is currently the most
damaging foliar disease on winter oilseed rape (Brassica napus) in the
UK. Deployment of cultivar resistance remains an important aspect of
effective management of the disease. Nevertheless, the genetic basis
of resistance remains poorly understood and no B. napus resistance (R)
genes against P. brassicae have been cloned. In this talk, I will be
presenting the findings from my research on host resistance against P.
brassicae and specific interactions in this pathosystem. New
possibilities offered by genomic approaches for rapid identification
of R genes and pathogenicity determinants will also be discussed.</p>
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<p>Papers:</p>
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<li>Chinthani Karandeni Dewage et. al, "Interactions between Brassica Napus and Extracellular Fungal Pathogen Pyrenopeziza Brassicae"
, 2021, in preparation</li>
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<p><strong>Date:</strong> 2021/02/25 <br />
<strong>Time:</strong> 14:00 <br />
<strong>Location</strong>: online</p>